Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling
نویسندگان
چکیده
منابع مشابه
Uncoupled Couplings: Combined Fmri and 1h-mrs for the Study of the Neurovascular and Neurometabolic Coupling
Purpose Functional magnetic resonance imaging (fMRI) is the tool of choice for mapping brain function. Unfortunately, the blood oxygenation level dependent (BOLD) contrast is essentially a vascular effect and hence only an indirect measure of neural activity. Accordingly, BOLD is found to reflect synaptic, more than spiking, activity and it is potentially independent on energy requirements [1]....
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Neurons, by virtue of their complex and continuously changing signaling roles in brain, must be able to regulate access to energy in order to maintain their ability to communicate meaningful frequency-encoded information. This is accomplished by release of neurotransmitters to astrocytes that in turn signal the vascular system to increase cerebral blood flow (CBF). This process has been termed ...
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Functional neuroimaging signals are generated, in part, by increases in cerebral blood flow (CBF) evoked by mediators, such as nitric oxide and arachidonic acid derivatives that are released in response to increased neurotransmission. However, it is unknown whether the vascular and metabolic responses within a given brain area differ when local neuronal activity is evoked by an activity in the ...
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Neuronal activity in the brain is thought to be coupled to cerebral arterioles (functional hyperemia) through Ca2+ signals in astrocytes. Although functional hyperemia occurs rapidly, within seconds, such rapid signaling has not been demonstrated in situ, and Ca2+ measurements in parenchymal arterioles are still lacking. Using a laser scanning confocal microscope and fluorescence Ca2+ indicator...
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The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. ...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2016
ISSN: 0271-678X,1559-7016
DOI: 10.1177/0271678x16680637